{"id":231657,"date":"2022-07-26T16:37:56","date_gmt":"2022-07-26T16:37:56","guid":{"rendered":"https:\/\/equicord.com\/?page_id=231657"},"modified":"2022-07-26T17:05:28","modified_gmt":"2022-07-26T17:05:28","slug":"desarrollo-de-horstem","status":"publish","type":"page","link":"https:\/\/equicord.com\/en\/desarrollo-de-horstem\/","title":{"rendered":"Development"},"content":{"rendered":"

[et_pb_section fb_built=\u00bb1″ custom_padding_last_edited=\u00bbon|desktop\u00bb module_class=\u00bbsection-header\u00bb _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb background_enable_color=\u00bboff\u00bb use_background_color_gradient=\u00bbon\u00bb background_color_gradient_direction=\u00bb53deg\u00bb background_color_gradient_stops=\u00bb#24519b 35%|#78a9cc 100%\u00bb background_color_gradient_start=\u00bb#24519b\u00bb background_color_gradient_start_position=\u00bb35%\u00bb background_color_gradient_end=\u00bb#78a9cc\u00bb background_image=\u00bbhttps:\/\/equicord.com\/wp-content\/uploads\/ventajas4.jpg\u00bb background_blend=\u00bbsoft-light\u00bb custom_padding=\u00bb8vw||12vw||false|false\u00bb custom_padding_tablet=\u00bb5rem||8rem||false|false\u00bb custom_padding_phone=\u00bb3rem||5rem||false|false\u00bb bottom_divider_style=\u00bbramp\u00bb bottom_divider_color=\u00bb#ffffff\u00bb bottom_divider_height=\u00bb5vw\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb text_font=\u00bb|300|||||||\u00bb text_text_color=\u00bb#e3edf4″ text_font_size=\u00bb1.15rem\u00bb text_line_height=\u00bb1.5rem\u00bb header_text_color=\u00bb#ffffff\u00bb header_font_size=\u00bb3.5rem\u00bb header_line_height=\u00bb3.8rem\u00bb max_width=\u00bb50%\u00bb max_width_tablet=\u00bb75%\u00bb max_width_phone=\u00bb80%\u00bb max_width_last_edited=\u00bbon|phone\u00bb text_font_size_tablet=\u00bb1rem\u00bb text_font_size_phone=\u00bb0.9rem\u00bb text_font_size_last_edited=\u00bbon|desktop\u00bb text_line_height_tablet=\u00bb1.4rem\u00bb text_line_height_phone=\u00bb1.3rem\u00bb text_line_height_last_edited=\u00bbon|phone\u00bb header_font_size_tablet=\u00bb3rem\u00bb header_font_size_phone=\u00bb2.2rem\u00bb header_font_size_last_edited=\u00bbon|phone\u00bb header_line_height_tablet=\u00bb3.3rem\u00bb header_line_height_phone=\u00bb2.5rem\u00bb header_line_height_last_edited=\u00bbon|phone\u00bb global_colors_info=\u00bb{}\u00bb]Horstem<\/span><\/p>\n

Development<\/h1>\n

EquiCord has carried out an exhaustive research and development process to demonstrate the quality, safety and efficacy of Umbilical Cord Mesenchymal Stem Cells<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1″ custom_padding_last_edited=\u00bbon|desktop\u00bb _builder_version=\u00bb4.17.6″ _module_preset=\u00bbdefault\u00bb background_enable_color=\u00bboff\u00bb use_background_color_gradient=\u00bbon\u00bb background_color_gradient_direction=\u00bb0deg\u00bb background_color_gradient_stops=\u00bbrgba(36,81,155,0.13) 0%|rgba(36,81,155,0) 100%\u00bb background_color_gradient_start=\u00bbrgba(36,81,155,0.22)\u00bb background_color_gradient_end=\u00bbrgba(36,81,155,0.12)\u00bb custom_padding=\u00bb||6vw||false|false\u00bb custom_padding_tablet=\u00bb||8vw||false|false\u00bb custom_padding_phone=\u00bb||6vw||false|false\u00bb top_divider_color=\u00bb#ffffff\u00bb top_divider_height=\u00bb3vw\u00bb top_divider_flip=\u00bbhorizontal\u00bb bottom_divider_color=\u00bb#262626″ bottom_divider_height=\u00bb2vw\u00bb bottom_divider_flip=\u00bbhorizontal\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb3vw||||false|false\u00bb custom_margin_tablet=\u00bb\u00bb custom_margin_phone=\u00bb\u00bb custom_margin_last_edited=\u00bbon|phone\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb header_2_font=\u00bb||||||||\u00bb header_2_font_size=\u00bb3em\u00bb header_4_font=\u00bb||||||||\u00bb header_2_font_size_tablet=\u00bb2.5em\u00bb header_2_font_size_phone=\u00bb2.2em\u00bb header_2_font_size_last_edited=\u00bbon|desktop\u00bb header_4_text_color_tablet=\u00bb\u00bb header_4_text_color_phone=\u00bb\u00bb header_4_text_color_last_edited=\u00bbon|desktop\u00bb header_4_font_size_tablet=\u00bb\u00bb header_4_font_size_phone=\u00bb\u00bb header_4_font_size_last_edited=\u00bbon|desktop\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

Clinical development<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb2_5,3_5″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb custom_margin_tablet=\u00bb\u00bb custom_margin_phone=\u00bb\u00bb custom_margin_last_edited=\u00bbon|phone\u00bb custom_padding=\u00bb0px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb2_5″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb header_3_font_size=\u00bb44px\u00bb global_colors_info=\u00bb{}\u00bb]La autorizaci\u00f3n de un producto como medicamento veterinario requiere de la realizaci\u00f3n de diversos ensayos cl\u00ednicos con el fin de garantizar la seguridad y eficacia del medicamento.[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb3_5″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb text_font=\u00bb||||||||\u00bb text_text_color=\u00bb#24519b\u00bb text_font_size=\u00bb1.5em\u00bb text_line_height=\u00bb1.6rem\u00bb header_4_font_size=\u00bb22px\u00bb custom_padding_tablet=\u00bb\u00bb custom_padding_phone=\u00bb\u00bb custom_padding_last_edited=\u00bbon|phone\u00bb custom_css_main_element=\u00bbfont-weight: 500;\u00bb global_colors_info=\u00bb{}\u00bb]En EquiCord hemos llevado a cabo 7 ensayos cl\u00ednicos para la autorizaci\u00f3n de comercializaci\u00f3n y actualmente estamos desarrollando 3 ensayos m\u00e1s.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb2rem||||false|false\u00bb custom_padding=\u00bb||12px|||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text module_class=\u00bblemon\u00bb _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb header_3_font_size=\u00bb1.8em\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

Safety and efficacy of MSCs in equine OA<\/h3>\n

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Preclinical<\/h3>\n

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Proof of Concept<\/p>\n

Assay on the safety <\/strong> of intra-articular application of allogenic mesenchymal stem cells from equine umbilical cord in healthy horses <\/strong><\/p>\n

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Phase I<\/h3>\n

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Single and repeated dose<\/p>\n

*VICH GL9<\/strong><\/p>\n

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Immunogenicity clinical trial: Cellular and Humoral response<\/p>\n

*VICH GL9<\/strong><\/p>\n

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Inmunogenicity<\/strong> clinical trial: Cellular and Humoral response<\/p>\n

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Phase II<\/h3>\n

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Proof of concept for determining safety and efficacy <\/STRONG>in intra-articular administration of the doses selected<\/STRONG> of allogenic umbilical cord mesenchymal stem cells in horses with degenerative joint disease<\/p>\n

*VICH GL9<\/strong><\/p>\n

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Phase III<\/h3>\n

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Determination of safety and efficacy <\/strong>in intra-articular administration of allogenic mesenchymal stem cells from umbilical cord in horses with degenerative joint disease<\/p>\n

*VICH GL9<\/strong><\/p>\n

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Efficacy and safety<\/strong> study of allogenic mesenchymal stem cells from umbilical cord for the treatment of clinical symptomatology associated with mild to moderate degenerative joint disease <\/strong>(OA) in horses under field conditions<\/p>\n

*VICH GL9<\/strong><\/p>\n

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Phase IV<\/h3>\n

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Long term follow up study:<\/strong>
Efficacy and safety study 2 years after HorStem administration<\/p>\n

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Post-authorization Survey Study\u00a0 <\/strong>about HorStem\u00b4s Safety and Efficacy in 800 horses<\/p>\n

 <\/p>\n

*VICH GL9<\/strong><\/p>\n

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Clinical results<\/h2>\n

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Clinical trials designed and conducted by our scientific team have shown that HorStem is effective in reducing lameness in horses with mild to moderate degenerative joint disease.<\/p>\n

All of our clinical trials have been carried out following the international standards for the homogenisation of clinical trials VICH GL9 and after authorisation from the Spanish Agency of Medicines and Health Products (AEMPS).<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb text_text_color=\u00bb#ffffff\u00bb text_font_size=\u00bb1.6em\u00bb text_line_height=\u00bb1.3em\u00bb custom_margin=\u00bb||5px||false|false\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

72% of the treated horses reduced their degree of lameness to absence of lameness or inconsistent lameness<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb text_text_color=\u00bb#ffffff\u00bb text_font_size=\u00bb0.95em\u00bb text_line_height=\u00bb1.5em\u00bb global_colors_info=\u00bb{}\u00bb](\u2264 grado 1 acorde a la Escala Americana de Veterinarios Especialistas en \u00c9quidos).[\/et_pb_text][et_pb_text _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb text_text_color=\u00bb#a9c5e0″ global_colors_info=\u00bb{}\u00bb]<\/p>\n

Likewise, long-term studies have shown that the efficacy of HorStem is very long-term, showing that 83% of the animals did not relapse in their symptoms or need additional medication 12 months after the application of HorStem.<\/strong><\/p>\n

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Horstem Desarrollo EquiCord ha llevado a cabo un exhaustivo proceso de investigaci\u00f3n y desarrollo para demostrar la calidad, seguridad y eficacia de las c\u00e9lulas madre de cord\u00f3n umbilical.Desarrollo cl\u00ednicoLa autorizaci\u00f3n de un producto como medicamento veterinario requiere de la realizaci\u00f3n de diversos ensayos cl\u00ednicos con el fin de garantizar la seguridad y eficacia del medicamento.En […]<\/p>","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false},"_links":{"self":[{"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/pages\/231657"}],"collection":[{"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/comments?post=231657"}],"version-history":[{"count":6,"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/pages\/231657\/revisions"}],"predecessor-version":[{"id":231679,"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/pages\/231657\/revisions\/231679"}],"wp:attachment":[{"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/media?parent=231657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}