{"id":333,"date":"2026-10-26T16:23:12","date_gmt":"2026-10-26T15:23:12","guid":{"rendered":"https:\/\/equicord.com\/?page_id=333"},"modified":"2026-10-30T13:49:31","modified_gmt":"2026-10-30T12:49:31","slug":"desarrollo-de-horstem","status":"publish","type":"page","link":"https:\/\/equicord.com\/en\/desarrollo-de-horstem\/","title":{"rendered":"HorStem Development"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"333\" class=\"elementor elementor-333\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3277ef2 e-flex e-con-boxed e-con e-parent\" data-id=\"3277ef2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_bottom&quot;:&quot;waves&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M421.9,6.5c22.6-2.5,51.5,0.4,75.5,5.3c23.6,4.9,70.9,23.5,100.5,35.7c75.8,32.2,133.7,44.5,192.6,49.7\tc23.6,2.1,48.7,3.5,103.4-2.5c54.7-6,106.2-25.6,106.2-25.6V0H0v30.3c0,0,72,32.6,158.4,30.5c39.2-0.7,92.8-6.7,134-22.4\tc21.2-8.1,52.2-18.2,79.7-24.2C399.3,7.9,411.6,7.5,421.9,6.5z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-40cf96d elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"40cf96d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"header-top-title\">HorStem<\/span><\/p><h1 class=\"title\">Development<\/h1><p class=\"title\">EquiCord has conducted an exhaustive research and development process to demonstrate the quality, safety, and efficacy of umbilical cord stem cells.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-83fcf55 e-flex e-con-boxed e-con e-parent\" data-id=\"83fcf55\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<h2 data-interaction-id=\"caf665a\" class=\"e-caf665a-f8d2691 e-heading-base e-default-h2\">Clinical Development<\/h2>\n\t\t<div class=\"elementor-element elementor-element-8a13d15 e-con e-atomic-element e-grid-base e-default-div e-8a13d15-aa26e78\" data-id=\"8a13d15\" data-element_type=\"e-grid\" data-e-type=\"e-grid\" data-interaction-id=\"8a13d15\">\n    <div class=\"elementor-element elementor-element-87e48c0 e-flex e-con-boxed e-con e-parent\" data-id=\"87e48c0\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0476ba3 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"0476ba3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Authorizing a product as a veterinary medicine requires conducting various clinical trials to ensure the safety and efficacy of the medicine.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3626608 e-flex e-con-boxed e-con e-parent\" data-id=\"3626608\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef67737 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"ef67737\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>At EquiCord we have conducted 7 clinical trials for marketing authorization and are currently developing 3 more trials.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-448b5fc e-flex e-con-boxed e-con e-parent\" data-id=\"448b5fc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<h3 data-interaction-id=\"75db6cb\" class=\"e-75db6cb-c076742 e-heading-base e-default-h3\">Safety and efficacy of MSCs in equine OA<\/h3>\n\t\t<div class=\"elementor-element elementor-element-5487120 e-con e-atomic-element e-grid-base e-default-div e-5487120-a75ab8a\" data-id=\"5487120\" data-element_type=\"e-grid\" data-e-type=\"e-grid\" data-interaction-id=\"5487120\">\n    <div class=\"elementor-element elementor-element-b52003e e-flex e-con-boxed e-con e-parent\" data-id=\"b52003e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<h3 data-interaction-id=\"dbc5b19\" class=\"e-dbc5b19-d54427e e-heading-base e-default-h3\">Preclinical<\/h3>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c802c3 elementor-widget elementor-widget-text-editor\" data-id=\"1c802c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Proof of concept:<\/p><p class=\"translation-block\"><strong>Safety<\/strong> of the intra-articular allogeneic use of equine umbilical cord mesenchymal stem cells in healthy horses<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ab68d61 e-flex e-con-boxed e-con e-parent\" data-id=\"ab68d61\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<h3 data-interaction-id=\"4bcb7d4\" class=\"e-4bcb7d4-51955c4 e-heading-base e-default-h3\">Phase I<\/h3>\n\t\t\t\t<div class=\"elementor-element elementor-element-bd2ddee elementor-widget elementor-widget-text-editor\" data-id=\"bd2ddee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"translation-block\">Safety Study in Target Species: <strong>Single and Repeated Dose<\/strong><\/li><\/ul><p style=\"text-align: center;\"><strong>*VICH GL9<\/strong><\/p><ul><li class=\"translation-block\">Clinical trial Immunogenicity: Cellular and Humoral response<\/li><\/ul><p style=\"text-align: center;\"><strong>*VICH GL9<\/strong><\/p><ul><li class=\"translation-block\">Clinical Study on Tumor Genesis<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9032bf9 e-flex e-con-boxed e-con e-parent\" data-id=\"9032bf9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<h3 data-interaction-id=\"bc8f935\" class=\"e-bc8f935-68ce7a7 e-heading-base e-default-h3\">Phase II<\/h3>\n\t\t\t\t<div class=\"elementor-element elementor-element-dbe21d5 elementor-widget elementor-widget-text-editor\" data-id=\"dbe21d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Proof of concept:<\/p><p class=\"translation-block\">Safety and efficacy investigation of intra-articular administration of selected doses of allogeneic umbilical cord stem cells in horses with degenerative joint disease<\/p><p style=\"text-align: center;\"><strong>*VICH GL9<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-64fead6 e-flex e-con-boxed e-con e-parent\" data-id=\"64fead6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<h3 data-interaction-id=\"5b543f1\" class=\"e-5b543f1-274fbfb e-heading-base e-default-h3\">Phase III<\/h3>\n\t\t\t\t<div class=\"elementor-element elementor-element-3051c00 elementor-widget elementor-widget-text-editor\" data-id=\"3051c00\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"translation-block\">Determination of the safety and efficacy of EUC-MSCs in the symptomatic treatment associated with degenerative joint disease (osteoarthritis) in horses under field conditions<\/li><\/ul><p style=\"text-align: center;\"><strong>*VICH GL9<\/strong><\/p><ul><li class=\"translation-block\">Confirmation of the safety and efficacy of intra-articular administration of allogeneic umbilical cord mesenchymal stem cells in horses with degenerative disease<\/li><\/ul><p style=\"text-align: center;\"><strong>*VICH GL9<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-da52185 e-flex e-con-boxed e-con e-parent\" data-id=\"da52185\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<h3 data-interaction-id=\"575078a\" class=\"e-575078a-e8bee79 e-heading-base e-default-h3\">Phase IV<\/h3>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef060f2 elementor-widget elementor-widget-text-editor\" data-id=\"ef060f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"translation-block\">Long-term safety and efficacy study: two-year follow-up safety and efficacy study<\/li><li class=\"translation-block\">Post-marketing survey study in 800 horses on the safety and efficacy of HorStem<\/li><\/ul><p style=\"text-align: center;\"><strong>*VICH GL9<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-baacbae e-flex e-con-boxed e-con e-parent\" data-id=\"baacbae\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;shape_divider_top&quot;:&quot;curve-asymmetrical&quot;,&quot;shape_divider_top_negative&quot;:&quot;yes&quot;,&quot;shape_divider_bottom&quot;:&quot;triangle&quot;,&quot;shape_divider_bottom_negative&quot;:&quot;yes&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"true\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M615.2,96.7C240.2,97.8,0,18.9,0,0v100h1000V0C1000,19.2,989.8,96,615.2,96.7z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"true\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M500.2,94.7L0,0v100h1000V0L500.2,94.7z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d20e59 elementor-widget elementor-widget-text-editor\" data-id=\"4d20e59\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h2 style=\"text-align: center;\">Mechanism of action of MSCs<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d8f214c e-con e-atomic-element e-grid-base e-default-div e-d8f214c-525b621\" data-id=\"d8f214c\" data-element_type=\"e-grid\" data-e-type=\"e-grid\" data-interaction-id=\"d8f214c\">\n    <div class=\"elementor-element elementor-element-cfa65c7 e-flex e-con-boxed e-con e-parent\" data-id=\"cfa65c7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<h2 data-interaction-id=\"89cf0cd\" class=\"e-89cf0cd-f303f17 e-heading-base e-default-h2\">Clinical results<\/h2>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe26217 elementor-widget elementor-widget-text-editor\" data-id=\"fe26217\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Clinical trials designed and conducted by our scientific team have shown that HorStem is effective in reducing lameness in horses with mild to moderate degenerative joint disease.<\/p><p>All our clinical trials have been carried out following the international regulations for the homogenization of clinical trials VICH GL9 and after authorization from the Spanish Agency for Medicines and Health Products (AEMPS).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6692719 elementor-widget elementor-widget-text-editor\" data-id=\"6692719\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>72% of the treated horses reduced their degree of lameness to no lameness or inconsistent lameness<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef4cc37 elementor-widget elementor-widget-text-editor\" data-id=\"ef4cc37\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>(\u2264 grade 1 according to the American Scale of Equine Veterinarians)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-701395d elementor-widget elementor-widget-text-editor\" data-id=\"701395d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"translation-block\">Likewise, long-term studies have shown that the effectiveness of HorStem is very long-lasting, <strong>showing that 83% of the animals did not relapse in their symptoms or need additional medication 12 months after the application of HorStem.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f19b39c elementor-widget elementor-widget-image\" data-id=\"f19b39c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"921\" src=\"https:\/\/equicord.com\/wp-content\/uploads\/2026\/10\/grafica_reduccion_cojera-889x1024.png\" class=\"attachment-large size-large wp-image-335\" alt=\"\" srcset=\"https:\/\/equicord.com\/wp-content\/uploads\/2026\/10\/grafica_reduccion_cojera-889x1024.png 889w, https:\/\/equicord.com\/wp-content\/uploads\/2026\/10\/grafica_reduccion_cojera-260x300.png 260w, https:\/\/equicord.com\/wp-content\/uploads\/2026\/10\/grafica_reduccion_cojera-768x885.png 768w, https:\/\/equicord.com\/wp-content\/uploads\/2026\/10\/grafica_reduccion_cojera-1333x1536.png 1333w, https:\/\/equicord.com\/wp-content\/uploads\/2026\/10\/grafica_reduccion_cojera.png 1425w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<div class=\"elementor-element elementor-element-ffc67ae elementor-align-center elementor-widget elementor-widget-button\" data-id=\"ffc67ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/equicord.com\/en\/nuestra-tecnologia\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-long-arrow-alt-right\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M313.941 216H12c-6.627 0-12 5.373-12 12v56c0 6.627 5.373 12 12 12h301.941v46.059c0 21.382 25.851 32.09 40.971 16.971l86.059-86.059c9.373-9.373 9.373-24.569 0-33.941l-86.059-86.059c-15.119-15.119-40.971-4.411-40.971 16.971V216z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DISCOVER OUR TECHNOLOGY<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>HorStem Desarrollo EquiCord ha llevado a cabo un exhaustivo proceso de investigaci\u00f3n y desarrollo para demostrar la calidad, seguridad y eficacia de las c\u00e9lulas madre de cord\u00f3n umbilical. Desarrollo Cl\u00ednico La autorizaci\u00f3n de un producto como medicamento veterinario requiere de la realizaci\u00f3n de diversos ensayos cl\u00ednicos con el fin de garantizar la seguridad y eficacia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_canvas","meta":{"footnotes":""},"class_list":["post-333","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/pages\/333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/comments?post=333"}],"version-history":[{"count":10,"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/pages\/333\/revisions"}],"predecessor-version":[{"id":450,"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/pages\/333\/revisions\/450"}],"wp:attachment":[{"href":"https:\/\/equicord.com\/en\/wp-json\/wp\/v2\/media?parent=333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}